Your surgeon has options: Why choose Titan Spine's Endoskeleton Technology?

Cage Image
The Endoskeleton's unique titanium,
acid-etched surface
Download an Endoskeleton Fact Sheet and Discussion Guide (PDF)

The Endoskeleton yields:

  • The potential for better bone formation response
  • The potential for faster healing
  • The potential for a stronger and more solid fusion1

Learn more about the unique bone-formation response enabled by Titan Spine’s surface technology. Watch this cellular animation:

How The Endoskeleton accomplishes this:

Unique textured surface stimulates a bone-forming response
Titan Spine implants feature the company’s patented surface technology, which creates a unique texture pattern on the device surface. This helps to secure the device in place, giving it better initial grip and implant stability. This increased grip also means the Titan implants are less likely to move out of place over time, which can happen with other implants.

Studies show this unique etched surface is superior to other implant material choices. The surface of most cages on the market today, typically made of polyetheretherketone (PEEK), ceramic or untreated metal (e.g., smooth titanium), are smooth at the micro and cellular levels. Therefore, they do not create the surface energy to stimulate a strong osteogenic (bone-forming) response.

A study reported in The Spine Journal in 2012 demonstrated the superior bone-forming response to Titan’s unique etched (i.e., not smooth) titanium implant surface when compared to smooth titanium and PEEK (Polyetheretherketone). 1

Has your spine surgeon offered you fusion surgery with a plastic (PEEK) implant?
Ask for the Titan Spine Endoskeleton acid-etched titanium implant instead.

Creation of natural BMP is accelerated, reducing or eliminating the need for artificial BMP
The process set in motion by Titan Spine's surface technology also stimulates the body to produce a naturally occurring bone formation protein, called BMP, to accelerate the fusion process. Many times with traditional interbody devices (typically plastic (PEEK) implants), spine surgeons will add artificial BMP to the bone graft. The use of external BMP may be helpful in some cases. However, their use can be costly, imprecise and, in certain cases, has been associated with serious side effects like soft tissue swelling, infection, nerve pain, and overabundant bone formation. 2,3

Titan Spine's implants encourage the body to produce its own BMP for a natural approach to enhancing fusion, reducing or eliminating the need for artficial BMP.

Together, the textured surface, bone-forming cells and natural BMP prompt the body to develop new bone around the implant site to strengthen and stabilize the spine. This enables Titan’s Endoskeleton implants to potentially support faster healing and a stronger and more solid fusion.

Risks associated with Endoskeleton Technology
As with all surgical procedures and implantable medical devices, there are associated risks, contraindications, warnings, and precautions. Please consult with your Physician to learn if you are an appropriate candidate for the Endoskeleton technology and to discuss all potential risks.

Take Action:


  1. R Olivares-Navarrete et al. Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic production on titanium alloy substrates than poly-ether-ether-ketone. The Spine Journal (March 2012, v. 12, p. 265-272)
  2. A Dmitriev et al. Bone morphogenetic protein-2 and spinal arthrodesis: the basic science perspective on protein interaction with the nervous system. The Spine Journal. 2011. Via
  3. D Benglis et al. A Comprehensive Review of the Safety Profile of Bone Morphogenetic Protein in Spine Surgery. Neurosurgery. 2008;62(5). Via
More Resources in the Patients Center