My PM has been trying to switch me from shorter half-life drugs to ER meds for better pain control and because I just didn't tolerate the way meds like Perocet made me feel (very unpleasant feeling, anxious) and only an incomplete pain relief of about an hour or so. So far I have tried Opana, MSContin and Kadian - none have given me significant pain relief but did give me such an unpleasant feeling and mood (even at the lowest dose possible) that I don't even want to think about increasing the dose recommended by my doc for pain control for fear those side effects will just be more prominent. (I just can't fathom anyone wanting to take these meds who is not is serious pain!!). I feel like I'm in a "lose-lose" situation. The only thing that seems to give me great relief without significant short-term affects are steroid injections, but we know long term those aren't good and are limited in number allowed/year. My pain is outright unbearable at times - well, many of you are/have been there. Is there anyone out there that had similar experience with these "feelings" but became tolerant to the negative side effects over time so they could increase the dose enough to get decent pain relief, and if so how long did it take? I have also been on Lyrica, Topomax, and now Elavil along with muscle relaxers too.