Welcome, Friend!

It looks like you're new here. If you want to get involved, click one of these buttons!

Veritas-Health LLC has recently released patient forums to our Arthritis-Health web site.

Please visit http://www.arthritis-health.com/forum

There are several patient story videos on Spine-Health that talk about Arthritis. Search on Patient stories
Protect anonymity
We strongly suggest that members do not include their email addresses. Once that is published , your email address is available to anyone on the internet , including hackers.

All discussions and comments that contain an external URL will be automatically moved to the spam queue. No external URL pointing to a medical web site is permitted. Forum rules also indicate that you need prior moderator approval. If you are going to post an external URL, contact one of the moderators to get their approval.
Attention New Members
Your initial discussion or comment automatically is sent to a moderator's approval queue before it can be published.
There are no medical professionals on this forum side of the site. Therefore, no one is capable or permitted to provide any type of medical advice.
This includes any analysis, interpretation, or advice based on any diagnostic test

prozac vs wellbutrin?

tarheelgirlttarheelgirl Posts: 473
edited 06/11/2012 - 8:46 AM in Pain Medications
Just wondering if anyone has tried both of these and which worked better for you. I've taken wellbutrin in the past and did well with it. About two months ago, my doctor put me on prozac. I had an appt today and told him that me nor my hubby could tell a difference being on the prozac...so he's switching me to wellbutrin. I know my depression is directly related to my chronic pain issues...not being able to do what I used to is a BIG one. Anyway, any feedback would be appreciated. Thanks.


  • I take wellbutrin and seems to help somewhat but had some minor adjustments as I found it keeps me up at night well, even more so then before. I hope it helps this time again for you. Charry
    DDD of lumbar spine with sciatica to left hip,leg and foot. L4-L5 posterior disc bulge with prominent facets, L5-S1 prominent facets with a posterior osteocartilaginous bar. Mild bilateral foraminal narrowing c-spine c4-c7 RN
  • Prozac works on seratonin, while wellbutrin works mostly on dopamine. I was suprised your doctor did that switch rather than trying another SSRI, but I hope the wellbutrin does the trick!

    Honestly, I don't know why he didn't put you on Cymbalta. Maybe the cost? Yes, probably that :( I pay $51 WITH insurance. Crazy stuff when there is no generic.

    Anyway, if the depression continues, just like the spine, ask for a referral to a psychiatrist. They know the drugs. There are mix and match things they can do that are impossible for any GP to know all about. Also, I highly recommend counseling!

  • I didn't get on very well with any of the serotonin-affecting drugs I was prescribed - fluoxetine (Prozac), paroxetine (Seroxat), escitalopram (Cipralex), and so on. I was initially prescribed Prozac, tramadol and Demerol, all at the same time - a real witch's brew and an open invitation for the development of Serotonin Syndrome (fortunately I didn't get it). I actually found I got better results (definitely in terms of pain relief) from the old group of antidepressants, the tricyclics. The only problem was the troublesome array of side effects. I haven't tried the newer types, such as duloxetine and venlafaxine.

    Bupropion (Wellbutrin) has more of a stimulant effect than many other antidepressants. It's believed to work by affecting noradrenaline and dopamine neurotransmission (as HappyHBmom pointed out). It's actually quite similar in structure to some of the popular diet pills used in the past, such as diethylpropion (Tenuate, Apisate, etc.), so no wonder it has been keeping you up at night, Charry! The main concern with it seems to be the increased risk of convulsions, as it lowers the seizure threshold, and there are warnings against using it together with drugs that share this effect (including tramadol and many of the antidepressants).
  • FYI, I have been on, at one time or another, most of the antidepressants known to man ;) I've been on Wellbutrin in combination with SSRIs and SNRIs. It is supposed to have a positive effect on motivation and energy and mood, without the weight gain and sexual side effects of some of the others. Downside is that it just doesn't work for a lot of people, because most people don't need more dopamine. So mostly it is now used as an adjunct (an additive to another antidepressant).

    The issue is that you were taking 10 mg Prozac a day, right? The recommended dose for major depressive disorder (which is the FDA approved use) is 20 mg a day, so you weren't even on a therapeutic dose. And, honestly, the SSRIs are much more effective percentage-wise than any other anti-depressant medication for treatment of depression.

    So, not saying you should do anything, just giving you some information. This is why I like to go to specialists for this sort of thing. :)

  • Thanks!
    for all the comments. First of all, Charry, I liked your little motorcycle for your picture instead of the goth one...the goth girl always scares me! lol It doesn't take much, huh? I'm being silly. I have the post hearing crazziness!! What dose do you take? 150mg moring and night?

    I know Wellbutrin is more for stimulant...I need that side effect. I need a kick in the booty to motivate me. I have been on Wellburtin twice before (both for post partum depp, and I couldn't remember any unwanted side effects, so I asked about it.

    I have taken celexa before...sleep, sleep...all I could do!

    I tried paxil...felt like I was floating outside my body...very freaky, so stopped that one asap.

    I was put on cymbalta when it first came out in the US and I was in that small percentage of those who couldn't pee. Had to cath myself a few days until it wore off.

    Let's see...oh yeah, I was put on Lexapro when my ex left for another woman...it was for depression, but more for anxiety. It helped, but good grief!!! I could not get off the stuff!! I tried many attempts and finally was successful shaving tiny peices off at a time. So I swore I'm never go back on them again!

    And here I am. My doc said that I can switch from Prozac (oh yeah, i started on 10mg, but been on 20mg a few weeks now0 directly to the wellbutrin with no side effects. I'm wondering about this. I

    I just wonder how an antideppresnent is going to help when I am dpressed do to the pain, but the pain isnt going anywhere. Should I really treat the "depression"? Please, share your thoughts...
Sign In or Register to comment.