I've been on Oxy10 IR 2tabs every 4hrs (120mgs/day) for about 4-5yrs. Over the last year the effectiveness has gradually started to decrease. I'm also on 1mg Klonopin every 8hrs. I've been on the Klonopin since March when I was diagnosed with Crohns. Before that I had been on 10mg of Valium every 8hrs for about 4yrs that I used as a muscle relaxer. I tapered myself slowly off of the Valium because it was dragging me down more and more, I stayed off of all Benzos for about 8-9 months then was diagnosed with Crohns, the Klonopin helps my stomach. I have a 2 stage ACDF in my cervical spine with a 3 stage laminoplasty. I also have 3 herniated disc in my thoracic spine, 2 of which are causing significant spinal cord impaction. I have a tendon in my left shoulder that is torn in 3 places as well. So anyway that is my medical and medication history. My PM just switched me to 40mg/day Methadone, 20mg twice/day. I've been on the Methadone for about 5 days and while I've had no adverse effects to the medication it just isn't strong enough. At the absolute best it works as well as my old medicine but that is in very short bursts that are few and far between. Generally speaking it doesn't work as well as my previous medication. The positive thing is my PM did say after giving the medication 4-5 days to work to just come in, no appointment required, to titrate the dosage until a sufficient level is reached. Do many of you have experience going from Oxycodone to Methadone and how did it work out for you?