I'm a 37 year old woman who has chronic pain from a rear-end car accident in 2007. In 2010 I was prescribed 40 mg per day of Apo Ketorolac for nerve pain caused by bulging discs, DDD, erosive spinal arthritis and Syringomyelia. My GP originally prescribed it for 6 months and I took 20mg 2x daily for nearly 6 weeks.
Within days of beginning the Toradol I began to feel very unwell. I had headaches, shakes, vomited every time I ate (it began to look like coffee grounds in week 4 and 5), had terrible GI upset, pain and gastric reflux, diarrhea, heart pain. I was getting strange itchy rashes on my arms, face and neck (at the time I believed they were hives to something unknown as I have allergies). I sweated profusely at night.
My stomach got very distended and hard and and the sensation was as though my stomach muscles were being stretched and ripped apart. I drank a lot of milk and ate a lot of dairy as the burning in my stomach was so intense it was all I could do to lessen it.
In fewer than 5 weeks I gained nearly 20 pounds. My menstrual cycle changed completely. I now have much more cramping and pain in my abdomen during my periods and the flow is much lighter and spotty, coming and going over a week or two rather than the heavy, predictable periods I had my entire life. It has remained unpredictable.
I have not been able to lose the 20 pounds of weight that I gained while taking Toradol. I eat healthy and have tried medically supervised dieting. I just keep gaining weight and swelling up. My waist circumference can change up to 6 inches over a day. I am usually less puffy when I wake in the morning, but by the afternoon I will be quite swollen especially in my waist, and lately my thighs and knees. I have steadily gained another 20 pounds since 2010 and as I have been a lean, fit person all of my life it is quite difficult to deal with. I have gone from a size 6 to a 10-12 and up to a 14-16 on days that I am very swollen. I am 5'1'. After a lymph massage I can lose 10 lbs and 2-4 inches of width in my waist. My neck and face will go down significantly too.
For the last year I have been taking Vimovo 325mg 2x per day (Naproxen) but not daily. I take it on bad days and try to use alternative methods the rest of the time. My kidney and liver function is apparently normal.
My question is, can a medication like Toradol, taken for more than the 5 days that is recommended, harm my kidneys and or liver enough that my body is now unable to move fluid around properly? What tests do I need to find that out? How would it have affected my prostaglandins, mentrual cycle and renal system? Can the effects last for years and is it likely that the Naproxen is also having an effect?
I have consulted with a number of doctors, pharmacists, nurses, a physiatrist and an anaesthsiologist and the general consensus has been basically "that's unusual, that shouldn't happen and it's long out of your system by now." I am not sure at this point where to go from here. I need to know what questions to ask and which tests to request to figure out why my body is so full of fluid, why it's been so difficult to lose weight and how I change that.
Any help or advice would be immensely appreciated! Thank You!