I have DDD and osteoarthritis. Have been on a combination of anti-inflammatory and Tramadol. Together works very well. My problem is that the anti-inflammatory causes swelling to my left foot and leg, fingers and hands. When the swelling gets to the point where my shoes hurt then I don't take it for a few days and the swelling goes down but then the pain in my back gets to be too much and I can't get it under control with Tramadol alone. Does anyone know why anti-inflammatories cause swelling?