I had a very bad flare up that lasted 10 days. During this time I ran out of the co-codamol I take, 60mg/1g 4 times daily, and I discovered that without it, the pain is no worse. It is exactly the same. I guess my body has become tolerant to it. I've stopped using it now and I'm just wondering how long I need to abstain from it for it to become effective again. Does anybody know?