I have developed piriformis syndrome over the last several months, I've been to the doctor he gave me muscle relaxers and percoscet initially for pain and told me to start stretching my Hamstrings (the meds were only short term so I could get some sleep). This had happened to me 2 years ago and I began riding my bike and the pain disappeared, so I did the same this time. The pain went away for a week but then came back. The difference between 2 years ago and now is 1) I'm 2 years older and 2)I've gained 40 pounds from Zoloft. Could my weight gain be hindering my healing this time?