I know a lot of folks here use Zanaflex, and I've heard wonderful things about it, so I wasn't too concerned when the surgeon gave my mom a script yesterday to replace the Flexeril, which wasn't touching her muscle spasms. This was her 6 wk checkup after fusion of L5-S1.
Got mom home, gave her a 4mg Zanaflex and about 20 minutes later she was deeply lethargic and slurrying her words. She said she felt like she was going to pass out. Later, she would tell me she felt like she was dying.
I got on the Internet and lo and behold, I find out the FDA issued a warning about the concomitant use of Zanaflex and Cipro. Mom's been on Cipro for several weeks to treat a UTI. I had given her the Cipro about 2 hours before the Zanaflex.
Cipro can potentiate the effects of Zanaflex "10 to 24 times", according to one article I found. By the time I got off the Internet to go back and tell mom what I'd found, she was for all intents and purposes, unconscious. I was a paramedic for 13 years, so, I took her blood pressure and it was nonexistent; took it 3 times. She had no radial pulse (at the wrist) and her respirations were very shallow.
I propped her feet up and about 5 minutes later had gotten her B/P up to 80/50 and she was more alert, but her speech was very, very slurred and she was deeply lethargic. She was in a deep sleep for the remainder of the night, as I monitored her vital signs.
You can Google "Zanaflex and Cipro" to find several references to the FDA warning. Here's a few:http://newsgroups.derkeiler.com/Archive/Alt/alt.support.mult-sclerosis/2007-04/msg00522.htmlhttp://firstwatch.jwatch.org/cgi/content/full/2007/412/2http://www.fda.gov/medwatch/safety/2007/safety07.htm#Zanaflexhttp://www.innovations-report.de/html/berichte/biowissenschaften_chemie/bericht-37884.html
Needless to say, I'm pretty irate that mom's surgeon didn't know about the FDA warning and mom's pharmacy didn't catch it either. I told the doctor's nurse yesterday, first thing, that she was on a new med, Cipro, since the last checkup; I again confirmed for the doctor that she was still being treated for the UTI, so he knew she was on it.
Moral of the story: Never take a new medication without doing your research first! No one else is looking out for your best interest. Be your own advocate.