Sciatica Caused by Disc Degeneration Sciatica can occur as a symptom of disc degeneration. When a disc degenerates, proteins are released. These proteins irritate the adjacent nerve. Further Reading: What Is Degenerative Disc Disease? Related Articles Lumbar Degenerative Disc Disease (DDD)Sciatica SymptomsSciatica CausesSciatica Treatment Related Videos Lumbar Degenerative Disc Disease VideoLumbar degenerative disc disease refers to the symptoms of lower back pain and/or radiating pain, numbness or weakness in the legs stemming from a degenerated spinal discSciatica Causes and Treatments VideoLearn about the possible causes of sciatica and the various treatment options such as medications, exercise, surgery, and steroid injections.Sciatica Animated VideoSciatica is leg pain caused by a problem in the low back. Watch an animated video that details the causes and symptoms of sciatica. Video: What Is a Degenerative Disc and the Degenerative Cascade?This video defines disc degeneration, which is the root cause of many disc problems, and the degenerative cascade.