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Allergic reaction to BMP

mmoore62mmmoore62 Posts: 1
edited 06/11/2012 - 7:22 AM in Back Surgery and Neck Surgery
:) Hello: I recently read the note about a possible allergic reaction to BMP. I recently had lumbar surgery with BMP and about 1 week post surgery I started to break out in hives and unbearable itching. My face, eyelids, and body were swollen and I was in constant misery. They put me on prednisone, which seemed to calm down this inflammation and Atarax. As soon as I came off the prednisone it started all over again, so I am now back on it again. They did blood work, which did not show anything, so now I am just waiting to see what happens after I am off prednisone again. This is sheer misery. I was doing very, very well post surgery, and was able to move around very well. This is my second lumbar surgery and I have also had cervical surgery as well. This is the first time, however, with the use of the BMP. I am wondering if anyone else has had this experience.

I did research on the internet and did find that there is the possibility of allergic reactions, but they are often remote. My doctor told me that any foreign substance entered into the body is always a risk for developing some type of reaction. This is very puzzling to me, and one I hope never again to experience. Thanks.


  • Monique

    I had a suspected reaction to the BMP. I tried looking it up online too and really did not find much information at all on it.

    I did not have hives, but my right leg, the one that was progressively getting more and more numb (the one that had NO problems pre-surgery) was swollen.

    The Dr. said - after the second surgery, where he removed the BMP from the spinal canal, that he could not really say that the numbness WAS from an allergic reaction, or if it was a hemorrhage, but he did manage to halt the spread of the numbness with that follow-up surgery.

    Prior to the second surgery he said, "best to go in now instead of having to do it in say another 3 weeks". I was very grateful he was so proactive about it.

    He also asked me if I was allergic to meat, cheese, milk, cows. Yes cows. I guess the BMP is bovine in it's origin, yes bovine, as in a cow.

    I am not allergic to anything like that; cats, yes, cows and horses - well, only the dust on them.

    Do you have other swelling besides the hives? Do you have other stress in your life?

    Hive sources are just so hard to identify. My DH had them BAD years ago. Every single night, huge body-enveloping welts. The only thing we could connect them to was stress and evenings. There are just about a bazillion causes of hives that it's almost impossible to say any one thing is the source. Could it possibly be related to a medication? Have the Dr.'s considered any drug side effects?

    I'm glad you are getting the prednisone, sounds like the docs are really tracking it - I really really hope it is not the BMP, that would suck to have to go back in.

    Good luck and keep us posted, I'll be watching and wondering...
  • my was positively linked to the bmp allergic reaction althouth they said its very rare its did happen, they cant go in and just take it out that would be a mess. they wait to see if bone is going to lay down and the reaction will go if away. if not after 3 to 6 months they do a revision and thats from the front. i broke my neck and had a c5 fusion in 1990 and had no problems what so ever to this day. only difference they took bone from my hip, and not some freakin man made protien.
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  • smcbridessmcbride CaliforniaPosts: 1
    Maybe this will help someone else to know what I've experienced. I've been told that I probably have a reaction to the BMP (Bone Morphogeneitic Protein) used during my anterior L5-S1 Fusion (7/15/2016). I was doing well until Day 13 when I was unable to sleep. When I tried to sleep I had severe left leg pain, which was the side where I had pain prior to surgery. I was lucky to get 2 to 4 hours of sleep. I was worn out and very hurting. When I told the doc the symptoms, the diagnosis was a reaction to the BMP. Prior to surgery I was told that about 5% of people have a problematic reaction to the BMP. As I understand it, the BMP is used to help the cadaver disc thrive in the body (for lack of technical terms). I was given 5 days of Toradol. I'm not sure why, but I think it was to help with the reaction. It didn't help much with the pain or the problem of sleeping during the night. Finally, I was prescribed Gabapentin, which helps with nerve pain. I was finally able to get enough relief to sleep, but during the day the nerve pain varied from tolerable to very ouchy. It would surface in various parts of my leg and be achy or stingy or throbbing. I was told it should go away by week 6 after surgery. I have 12 days to go and am hopeful. I had to back slide in my routine of walking; however, I am now able to walk 20 minutes 3 times a day. I will add to this report if in fact the nerve pain does end at 6 weeks. I have to say, sometimes the pain is down right awful! I'd like to know more about BMP if I am ever faced with using it again. When the doc said 5%, I was definitely thinking - not me! I'd like to hear other patient's stories with BMP. THANKS!
  • My BMP reaction 

    1 week after my TDR and Alif surgery , I got the painful BMP reaction in my legs, it was teriable, it happened on a weekend and I didn't want to bother my surgeon even though I did have his number. Silly me but anyway I just managed to get through the weekend on 3 panadol every 3 hrs( not good you could damage ur liver) Monday morning 8.30am as soon as surgery opened I called and spoke to the nurse and told me I should have called that's why we give you the surgeons number. She was fantastic I told her how silly I felt after what I had put up with on the weekend. My surgeon was in theatre all day so she told me to go see a doctor and then get the doctor to call her and she would explain what he needed to prescribe for me, they gave me dexamazone to be taken 2 times a day for 5 days only and some heavy duty pain killers, thank god  and to come in and see my surgeon  the very next day. All I can say is it really helped. I am now 5 weeks post opp I still get leg pain but it's manageable and not that pain that had me in tears when it came on. Here they told me about 20% get this reaction and I was a lucky one not lol. I also had 2 lots of the BMP put in as I had 2 fusions.  
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