Please can someone help me solve a dispute i have going on with my friends . Depression is something i recognise and understand as i used to work in mental heath before all this with my back. I agree when your in pain 24/7 that you can get drepression. But i am just fed-up with being in pain. My friend says im depressed because im always in pain and i disagree with her. so the question i want to ask is, when your in pain 24/7 and fed-up does this mean that you are depressed? Is there a difference ?