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Grapefruit juice--did you know?

inchwormiinchworm Posts: 719
edited 06/11/2012 - 7:47 AM in Pain Medications
Just wondering if anyone else is aware that grapefruit juice will enhance the effects of your medication. I don't know what the property is in the grapefruit but can attest that it does work.

Only one caution: Grapefruit juice also enhances the effects of other medications as well. For instance, if you're statin drugs for lowering cholesterol, you need to be very careful because drinking grapefruit juice when you take your statin can cause severe liver damage. I take simvastatin and the package label has a warning that drinking grapefruit juice even one time while on the med can cause liver failure.

I drink grapefruit juice every day because I love it and so I had been at risk for some time without knowing it. So far I haven't had any ill effects--my liver is fine--but I hesitated to even post this in case someone else might not be so fortunate. Be careful with this info and do the safe thing, please.

2009 Foraminotomy C6-72010 PLIF L4-S1Multi RFA's, cervical inj, lumbar injLaminectomy L3-4 and fusion w/internal fixation T10-L4 July 17Fusion C2-C5 yet to be scheduled


  • Grapefruit juice does affect an enzyme called CYP3A4 in the P450 metabolism and does affect many medications, esp. benzodiazepines like valium etc. It can affect pain meds too - so its best to ask your pharmacist about the extent that it might affect your medication. There's controversy over to what degree it affects medications like oxycontin, then again so does a fatty meal. Usually, if there is a very significant interaction it will be on the drug label that comes with your prescription (that print out).
  • I know my Mother used to love grapefruit juice everyday but since her silent MI she's taking vasotec since she was 51 and she's 69 now and never drank another glass or eaten a grapefruit! Good post Linda. Charry
    DDD of lumbar spine with sciatica to left hip,leg and foot. L4-L5 posterior disc bulge with prominent facets, L5-S1 prominent facets with a posterior osteocartilaginous bar. Mild bilateral foraminal narrowing c-spine c4-c7 RN
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