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Interesting article I read today

firewater1981ffirewater1981 Posts: 85
edited 06/11/2012 - 7:51 AM in Alternative Treatments
I read an interesting article on MIT’s Technology Review today. It appears that scientist are looking at other approaches to treat herniated and degenerated discs. While you can make the argument that different approaches have been tried throughout the years with limited success we are seeing innovation and advancements today that are happening at breakneck speeds. I firmly believe that there will be something to help us coming up soon. Real soon. The procedure/method described in this article may not come to fruition but I believe within the next couple of years (4 or less) we will see something that radically changes the field for us Spineys. Ive been doing a lot of research on clinical trials and recently published medical documents. There is a light at the end of the tunnel and I believe it is coming real soon. Keep you head up people!

Here is that article I read today: You can read it for yourself by going to Technology review.com.

A Better Disc for Back Repair
Implants grown from living cells could offer better support and flexibility.
The back pain caused by a damaged intervertebral disc often requires surgery, which means either replacing the disc with a plastic or metal implant or removing the disc and fusing the adjacent ones together. A new type of replacement disc—consisting of a scaffold seeded with living cells—could relieve back pain without many of the side effects caused by existing surgical approaches.
Researchers at the Medical University of South Carolina made a prototype replacement disc by printing an outer scaffold and then seeding the scaffold with living cells. The scaffold closely mimics the intricately layered microstructure of a real intervertebral disc, and is the first step toward making an implant that can perform the same supportive and shock absorbing functions as the original. Compared to the metal and plastic implants used today, an artificial scaffold swathed in living tissue could repair itself, and constant access to blood supply would reduce the risk of infection after surgery.
An intervertebral disc, or IVD, is shaped like a jelly donut, with an soft, elastic center and a tougher, fibrous outer layer. Sandwiched between vertebrae in the spine, the disc defines and supports the spine's movement, holding bones in place while allowing the spine as a whole to bend and twist. The discs also act as shock absorbers, cushioning impacts to the spine. When a disc becomes worn, pressure along the spine is unevenly distributed, and if the vertebrae shift even slightly, they stretch the nerves circling the spine, causing pain. If exercise and physical therapy offer no relief, surgery may be required.
Spinal fusing, however, restricts bending and twisting in the fused section of the spine, so some surgeons make a strong case for the implant method. "None of us were born with fused spines," says Barton Sachs, a professor of orthopedics at the Medical College of South Carolina, who routinely performs disc-implant surgery and who was not connected with the new work. Fusing two bones together can increase the pressure on neighboring segments, wearing out other discs, Sachs says. Not only does an implant preserve motion, but the recovery time from implant surgery is shorter. "It works extremely well," says Sachs. "[Patients] get out of the hospital faster; they get back to their lifestyles faster."
But the implants currently used do not absorb shock. "You're putting in materials that look medieval, and that's the state of current clinical practice," says Robert Mauck, professor of orthopedic surgery and tissue engineering at the University of Pennsylvania. Mauck is working on a competing improvement to disc implants.
Researchers at the Medical University of South Carolina, led by Xuejun Wen, professor of bioengineering and regenerative medicine at Clemson University and the Medical University of South Carolina, tried to closely mimic the natural architecture of the disc, so that it can perform the same functions as the original.
First, they modeled the complex inner structure of the disc on a computer. Then they extruded dissolved polyurethane through a fine glass micropipette tip onto a platform kept at -4 degrees Celsius. The cool temperature of the base caused each printed layer to solidify quickly and allowed successive layers to stack on and maintain their shape. "If you don't cool it really quickly, you won't get the structure you want," says Wen. Finally, the group seeded bovine cells on the scaffold, to test if the structure supported cell growth. These grew to fill it over 19 days, after which the cells were found to have arranged themselves as they would in a natural disc.
"It's a clever application of additive manufacturing and an exciting piece of work," says James Iatridis, professor of orthopedics and neurosurgery at the Mount Sinai School of Medicine, in New York. But Iatridis adds that "several alternate approaches involving biological repair are nearing clinical trials or at more advanced stages of development."
While the new work by Wen and his group comes closest to replicating the microstructure of a real disc, its performance has yet to be tested. In the next few months, the discs will be tested in rats. "We're still trying to understand how complicated our engineered solutions need to be in order to restore function," says Mauck.



  • I am also very encouraged by these medical advances, finally!

    FYI at this time, options exist only in Mexico, China and South Korea..and I am not sure how many actual procedures have been done for our type of spinal issues or success rates. Anyone with personal experience out there or opinions on these exciting advances in regenerative medicine?

    Wendy S

  • firewater1981ffirewater1981 Posts: 85
    edited 06/14/2016 - 12:54 PM
    Wow, people are digging up my old posts, posts that I have long forgot about.

    Wendy, here are some of the links to articles I have found and saved over the years. As I said earlier in this original post I believe that we are only a few short years off from something really positively changing for us spineys. Maybe sooner for those that enroll in clinical trials if the product/procedure is viable.

    Here are some articles to investigate for yoursef:

    Articles of hope on back pain
    Articles I have found over time to give hope in the advancements of treating DDD and herniated discs

    Worlds first spinal transplant carried out

    Researchers growing new discs from scratch

    Transplanting good discs from deceased patients to patients with bad discs

    Interesting find may yield new avenue of treatment for herniated discs

    Vertebral disc regeneration

    Previous success with using Stem cells to treat DDD

    Current Clinical Trials using Stem cells to treat DDD

    Hope this helps. Even more I hope one (or more) of these products/procedures takes off. If you read all of those articles the stuff they are talking about has already been shown to work positively in humans and they are moving to phase 2 and 3 to test on a larger scale. I am keeping my fingers crossed.

    Take care!
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