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My switch from neurontin to lyrica has been amazing.

scmgurusscmguru Posts: 103
edited 06/11/2012 - 7:55 AM in Pain Medications
Ive been taking gabapentin now for well over a year and even at high doses (for me) of 1800mg/day it worked inconsistently from a pain management perspective.

I had a prescription for lyrica, but didnt try it because I was told i needed to taper the neurontin down to 0 and taper up the lyrica.

Recently, a physician i saw for a 2nd opinion suggested i switch to lyrica. He said i didnt need to taper, just switch over to an equivalent dose.

I didnt buy it.. So i stuck to the gabapentin.

About a week ago, i read an article re: how lyrica can treat anxiety issues as well.

Ive been having anxiety for the past year and most recently motivation issues.

A week ago i switched over, cold turkey. I figured, the worst that could happen is i feel awful and just switch back.

I started out with 150mg at bed time and have been taking 75mg, 3x a day for the past week.

Im amazed... I feel MUCH better than i did w/ gabapentin.

I feel like ive got much less neuropathic pain and even more importantly, i feel like a dark cloud has lifted.

My anxiety has been reduced by at least 50% and i am feeling better overall.

I cant say the pain is gone, but i feel a lot better than i did.

What i find so strange is, pregabalin and gabapentin are supposed to work on the same receptors

Whatever the reason.. Im sold.



  • If it helps who really knows why one will work better for one person than the other.
    I started on Lyrica a few weeks back and while it is giving some relief, just not sure it is giving enough. I do have the option to go up, but am cautiously watching my weight as well. I can say I don't have that drunk feeling I had from the neurontin so that I am thankful for. Like everyone here, I will take whatever relief I can get, from the nerve pain.
  • I was started on Lyrica 2 years ago come this December, and was started at 300mg a day. I am a curled up ball in the corner of the room without it! For me it knocks around 80-85% of my neuropathic pain down!!

    I did gain almost 50lbs on it, but over time I am nibbling that down. I've lost 28 of it so far, and still going. Lyrica is the first and only nerve pain medication I have tried. I'd be afraid to try anything else at this stage, as I am having great results on the first go! I'm very happy to hear of another with good results. :)

    PCTF C4 - T2, Laminectomies C5, C6 & C7. Severe Palsy left arm/hand.
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  • I gained about 10lb from neurontin .. I hope it doesn't go up too much.

    I wonder it the weight gain is water weight, since many people experience edema..
  • scmguru said:
    I gained about 10lb from neurontin .. I hope it doesn't go up too much.

    I wonder it the weight gain is water weight, since many people experience edema..
    My husband thinks most of mine is water weight. My GP won't give me water pills though! I've tried the OTC water pills, but they didn't seem to make a difference.

    I know I still have edema in my legs. I do the finger test - press a finger into the leg, hold it for a few seconds and release, the dimple stays for a bit...It's still a lot lower than its been. I've also cut out most of my processed foods and salt is much reduced = swelling in the legs went down big time!!

    PCTF C4 - T2, Laminectomies C5, C6 & C7. Severe Palsy left arm/hand.
  • The weight gain isn't just water weight. It makes you want to eat more and snack a lot. I picked up 20lbs thanks to it and I'm a small frame. It was all fat.

    Also watch out before you sing too many praises. It has a horrible side effect on memory also. Your short range memory will go down the hopper. After a few months of them I came to the opinion they are stupid pills. Try to focus and do a complex job while taking those. It'll drive you crazy.

    Sadly it did work great for the nerve pain at the time until I got the real problem repaired.
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  • I was on gabapentin for a about a year as well at 1800mg/day, and did the switch over to Lyrica without titrating the gaba. Lyrica was amazing for the pain for me, but I gained about 25 lbs in about 3 weeks, even though my appetite didn't change. A lot was water weight, as I dropped about 1/2 of the weight when I went off of it after 3 weeks, and the edema I had while on it disappeared as well. So, I've been back on gabapentin for the past year and a half since then. I don't have memory issues on either of these meds, although a lot of people do suffer from that. Everyone reacts differently to meds. I hope it works out well for you!
    APROUD CANADIANveteranButNOTa doctor, my thoughts are my own
  • Graham,

    I pretty much was never a snacker - still aren't, and as for increasing what I eat, nope, I actually have to make me eat as my appetite reduced once I got on Lyrica! I know I am retaining a lot more water than I should.

    As for memory, I lose little words, but otherwise I've not really had mental/memory issues on it. :)

    PCTF C4 - T2, Laminectomies C5, C6 & C7. Severe Palsy left arm/hand.
  • I am still very cautious with these meds, as with the neurontin one thing I did get was a severe case of double vision. I was up to 2400 mgs a day, so while it helped, the vision deal came on suddenly and as soon as i dropped it, the issue resolved. Also being I watched my mom with alzheimers I am very cautious with any meds effecting memory. Which one reason I am using this med very cautiously.

  • Brenda, Kelly, You gals are lucky or women get water weight. I got a big guy and moobs... It was not water weight and it did not go away after I stopped Lyrica. I had to wait a year. 6 months after the pills I got fused, add 6 months recovery. I hit the exercise full throttle and it took another 6 months to knock that stuff off.

    Tam yeah, watch out on the memory and have someone else monitor. Someone who is honest. Spouses sometimes yell you what you want to hear. My memory got bad and it affected my work badly. My best buddy covered for me and told me when I was doing it.

    Lyrica did rock for controlling the nerve pain though.

  • Not sure there is something to be fixed on my end.. I had an L5MicroD (Failed) and then an L5S1 fusion where the Dr. misplaced the pedicle screws, resulting in a revision laminotomy 7 days later to "fix the problem"

    I've now got pain I never had before in my back and legs.

    After stringing me along for months, my original surgeon kicked me over to pain management.

    I went and got a 2nd opinion about 6 weeks ago.. found out my original surgeon used BMP totally off label and against FDA guidelines without ever getting consent from me to do so.

    As a result, I've got new pain in my back and legs that was never there before and a horrendous inflammatory response that doesn't want to go down.

    My CT/MRI from July indicate I've got ectopic bone (from the BMP) growing in my left foraminal canal..

    I'm not even 40 yet.. :(

    I absolutely agree both Lyrica and Neurontin definitely affect memory. For me, Neurontin was much worse.. I called it Morontin.. because I felt like a moron.

    In any event

    However, I'm just trying to get by right now.. day to day and keeping my fingers crossed I can continue to support my wife and 6 month old baby.

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