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Please respond, does butrans patches make lortab not work

DixiechickDDixiechick Posts: 27
edited 06/11/2012 - 8:58 AM in Chronic Pain
I have posted recently and no one answered. My Dr put me on Butrans patch at 10 MG and it is not cutting it. I am in so much pain at this exact moment. I still have some old lortab but from what I have read it will make either the patch not work or the lortab will not work. It has something called an antagonist in it. I took one of the lortab this afternoon about 2 hours ago and now it seems I am in more pain. If someone, anyone has any insight to this I would appreciate it. I have called my Dr and have yet to get through to a nurse. I left a message yesterday about 24hours ago and have recieved no call back. I am just at my wits end. I see people reading and replying to others messages but not mine. If you have any thing to add to just make me understand I sure would appreciate it. Thank you.
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Comments

  • I was on Butrans patch 25-50 they helped a little but then it quit helping so now just on percocet,
    i dont know about your question, Rick ncpa
  • Butrans patch does stop another narcotic from working and you can probably find more information from your Pharmacist. But hope you hear from your Dr. soon. Try icing and heat also. Best wishes. Charry
    DDD of lumbar spine with sciatica to left hip,leg and foot. L4-L5 posterior disc bulge with prominent facets, L5-S1 prominent facets with a posterior osteocartilaginous bar. Mild bilateral foraminal narrowing c-spine c4-c7 RN
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  • I tried it - the doctor claimed it would let the lortab work, but the pharmacist said it would not. Everything I read about it said he was correct and I was in so much pain I thought I'd die. I couldn't even come to work I hurt so much on butrans. I hear it works great for some, not for me. Hope that helps a little.
  • Buprenorphine doesn't block the effects of other opioids in the analgesic dose range, although it is possible in higher doses. According to recent research:

    'The interaction of buprenorphine with mu-agonists in the analgesic dose range resulted in an additive to supra-additive effect. Statistical comparison with the respective theoretically additive value indicated pure additivity for the combination of buprenorphine with morphine and with hydromorphone and a moderate synergistic interaction for the combination with oxycodone. Importantly, in all of the experiments there was no indication of a sub-additive effect or antagonistic interaction. These results show that in the analgesic dose range, buprenorphine behaves in a manner similar to other mu-agonistic opioids. That is, by interacting with the same receptor type, it induces additive or slightly greater analgesic effects when combined with other mu-opioids.'

    - Buprenorphine: the Unique Opioid Analgesic - Pharmacology and Clinical Application' (2005) edited by Keith Budd & Robert B. Raffa

    The Palliative Care Formulary states:

    'In low doses, buprenorphine and morphine (or alternative mu-opioid receptor agonist) are additive in their effects; at very high doses of buprenorphine (>10mg/24hr?) antagonism could theoretically occur. However, with typical doses, it is possible to switch either way between buprenorphine and morphine (or other mu-opioid receptor agonist).'

    There are many more sources that confirm this, including my own pain management specialists both in the UK and here in Taiwan, and the information that comes with my regular Temgesic (sublingual buprenorphine) prescription also points out that antagonism or a blockade effect does not occur in analgesic doses. I've been taking buprenorphine for many years now and at the same time have been prescribed dihydrocodeine, tramadol, oxycodone and morphine for breakthrough pain, and the result has always been an increase in pain relief. Not one of the other patients I know who are on buprenorphine long-term have noted a negative effect with other mu-OR opioids.


    There is a lot of misunderstanding about this drug due to its unique pharmacology and its label as 'partial agonist' or 'agonist-antagonist'. Most of the negative feedback I have seen is from people who haven't given it a chance to start working - every drug of this type needs time to be titrated properly, according to the patient's requirements and circumstances. Some patients simply won't find it as effective as others, but this is the case with any opioid analgesic.


  • Thanks those are interesting articles showing that breakthrough meds will help lessen the pain. Charry
    DDD of lumbar spine with sciatica to left hip,leg and foot. L4-L5 posterior disc bulge with prominent facets, L5-S1 prominent facets with a posterior osteocartilaginous bar. Mild bilateral foraminal narrowing c-spine c4-c7 RN
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  • Glad you found them interesting, Charry.

    P.S. Hope you get some answers regarding your nerve pain soon.
  • Thank you so much. I am doing research. I just found out I have an hemangioma in an area that has felt like someone is stabbing me with an oyster knife. I am going to start a new thread. It is coming together.
  • Dixiechick said:
    I have posted recently and no one answered. My Dr put me on Butrans patch at 10 MG and it is not cutting it. I am in so much pain at this exact moment. I still have some old lortab but from what I have read it will make either the patch not work or the lortab will not work. It has something called an antagonist in it. I took one of the lortab this afternoon about 2 hours ago and now it seems I am in more pain. If someone, anyone has any insight to this I would appreciate it. I have called my Dr and have yet to get through to a nurse. I left a message yesterday about 24hours ago and have recieved no call back. I am just at my wits end. I see people reading and replying to others messages but not mine. If you have any thing to add to just make me understand I sure would appreciate it. Thank you.
    I know it has been about a year since UR post, but I've just started the patches 2 weeks ago & they have not helped my pain at all.. I 2 have a few lortab 10 left & I've took some of them & to me they help, but when I don't take them I'm in servere pain, buts thats why I was put on the patches, but to me it is a waste of money.. lortab works better & is alot cheaper.. Not I didn't get addicted 2 lortab.. but I say patches ant no good... Some ppls system is different tho... what works 4 1 may not work 4 another..
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