Hi all. I hope your November is starting off with less pain. Unfortunately the colder months in the Midwest are a challenge for most of us with arthritis issues. Quickly, I am a 50 yr old female DXed with Ankylosing Spondylitis five years ago. I've used NSAID for most of that time since my DX. Seven months ago I started taking hydrocodone (5s, now 10s). My rheumy put me on Humira, 40 mg injection pen every two weeks, last month. I've only had one injection. The second I am due to take this Thursday. My question(s) is/are...what should I expect? How long does it take to work? What's been your experience as far as side effects? Any tricks to taking it? Etc? So far I feel no differently. Maybe slightly (I mean I'm being very generous, like in my head) better. I was hoping to reduce my enthesitis by 50% or more. Is that expecting too much? Please give me your thoughts, opinions and experience if you've used Humira and for what disease. I am SO happy to be apart of this community. I've felt welcomed and helped tremendously by many so far. Ok? So let me have it!