Take 1 tablet by mouth three times a day as needed for pain. This instruction is on our pain medication and I have been told that I need the pain drug in my system before the pain really gets bad. Do most of you wait to take the pain medication till you start feeling pain? Do you take it every 5-8 hours to have the medication in your system? My cocktail prescribed is oxycodone 10/325. Just wondering how most of you deal with your pain medication? I hate taking pain meds, but I hate the pain a lot more.