COX-2 inhibitor refers to a relatively new class of non-steroidal anti-inflammatory drugs (NSAIDs) that targets the COX-2 enzyme specifically. These COX-2 inhibitors work by limiting the formation of inflammation, which is a common component of many forms of back pain and types of chronic pain.

The main advantage of the drug over traditional NSAIDs is that it inhibits the specific enzyme associated with inflammation, fever and pain without disrupting the enzyme associated with the integrity of the stomach lining and maintenance of platelet and kidney functions.

Hence, COX-2 inhibitors can be used in treating chronic pain-related inflammation with a minimal risk of gastrointestinal complications. COX-2 inhibitors do have their own unique potential risks and complications and are available only be prescription.