The injection technique involved in prolotherapy requires skill and care on the part of the physician. Training and experience are important.

Possible side effects may last a few days to a couple weeks and include:

  • Swelling
  • Intense pain and stiffness
  • Headache
  • Allergic reaction

Reports of more serious complications have been rare, but could include:

  • Spinal fluid leak
  • Permanent nerve damage or paralysis
  • Pneumothorax