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Generic Morphine Sulfate ER

Old WhitebeardOOld Whitebeard Posts: 23
edited 06/11/2012 - 7:53 AM in Pain Medications
Hi, everyone. I am an Internet engineer, not a pharmacologist. I would like to ask about your experience with generic oral morphine products.

I recently made the mistake of accepting Mallinckrodt Morphine Sulfate ER 30 mg as a generic substitute for MS Contin 30mg. These tablets made me sick. I still had some brand name MS Contin 30 mg (manufactured by Purdue Pharma, and yes, it is expensive) and I went back to the brand name drug, then tried the Mallinckrodt pill, and got even sicker.
Malaise, belching all day, nausea (but not the point of vomiting), stomach and intestines gurgling all day. The next day I took the brand name MS Contin 30 mg, and I felt much better. Better pain relief, no nausea. A little woozy at peak, but I can tolerate woozy; I cannot tolerate nausea all day.

I have found complaints about Mallinckrodt MS ER pills on other web sites. What does Mallinckrodt put in these pills that causes nausea? I called Mallinckrodt and asked that question to one of their pharmacists; there was a long pause before he said he did not know. He is going to send me a list of "inactive ingredients".

Last year I was using Morphine Sulfate CR by Watson Labs. It was as good as brand name MS Contin. I called Watson Pharmaceutical to find out where I could buy it this year. Watson rep told me they had stopped manufacturing morphine.

Several years ago CVS filled these prescriptions with MSER from Ethex. However, last year Ethex pleaded guilty to two felonies for not reporting manufacturing problems to the FDA. According to what I read, the parent company KV Pharmaceuticals closed Ethex.

Apparently Mallinckrodt is selling their inferior product into the void left by the withdrawal of Ethex and Watson from the market.

I am trying an off-green Morphine Sulfate ER 30 mg Endo tablet, which is available at one local pharmacy.

I would be interested in knowing more about the experiences of other people who get scripts for MS Contin. Have you used a generic MSER tablet from another manufacturer that was satisfactory?


  • MetalneckMetalneck The Island of Misfit toysPosts: 1,675
    Im on MScontin CR that I get from Walgreens .... it is a generic from RHODES. I haven't had any of the problems that you have mentioned but do have issues with other generics made by other companies (Fentynl patches - Watson vs Sandoz Vs Mylan - Only the Sandoz brand seems to work for me, and it is often back-ordered from the factory.

    So Yes .... I do beleive that some generics don't have the same effect and can cause adverse effects. I know that many of our chronic pain family members have had issues with the new formulation of Oxycontin. (gastric distress was one of the more often unwanted side effects).

    Talk with your pharacist and see what other brand they maybe able to order - or maybe switch pharmacys?


    Spine-Health Moderator
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  • I also have the generic from Mallinckrodt. Everytime I take them I am soooo sick. I will only take them if I am in extreme pain. Maybe I need to ask for a different brand?
  • My experience with Narcotic pain relievers has spanned the whole gambit. Being an engineer and my livelihood depends on my mental acuity; I have always been concerned about the long term effects of opiates on my cognition.
    What I have found is that our brains have what is called neuroplasticity and will become tolerant of any medication fairly shortly.
    Long acting opiods, while assisting with the pain, has a liability. That liability is that the side effects become more predominant and their ability to reduce pain decreases with dose.
    The other effect long acting opiates have is that they actually will proliferate the opioid receptors. Thus making one more sensitive to pain and many times the pain increases.
    The strategy that has worked very well with me is in taking immediate release pain medication. My evening dose is a few hours before I go to sleep.
    For those times the pain does not wake me up, my neurotransmitters and receptors have a break. In some cases I wake with withdrawal symptoms.
    However, the benefit of this course has been that I have been able to maintain the dose for pain for years. My tolerance does not build as quickly.
    Those times when the pain is not that severe I taper down to give my brain a break.
    I have witnessed other pain patients who have continued taking long acting narcotics and most , if not all, begin a precipitous decline including depression and more pain.
    I refuse to succumb to the memory loss and the mental decline I have seen with others. While I have had to battle with the doctors to allow me to continue taking short acting; relatively recent articles in scientific and medical journals bears my approach.
    My life would be too difficult to continue. The quality of life is so diminished that I would (and have) contemplated ways to find permanent relief.
    Before beginning my narcotic regime, I was irritable and just an asshole to family and friends.
    Narcotics have been a life saver to me and I believe that others should benefit from the relief I have now. So I try harder to care for others and try to be helpful.
    The brain is very adaptive and can accommodate the pain medication at great cost to your personality and your intellect.
    Yes its difficult once a month to reduce the medication but then it works more effectively for me and I can recenter myself.
    Before I did this I was taking so many long acting that I was a zombie and so out of it...it is your body and physicians may not have experienced the long term degradation associated with long acting opiods.
    Manager your life and at least limit long acting to only once or twice a week. Get some short acting ones and find the right dose. BTW - with short acting you can also better titrate your pain level.
    I hate the nightmares that accompany taking too much and do not want to sink into that condition called "morphine-ism " this is a condition where your passion for life simply drips away.
    Pain meds are to improve the quality of life so that you can contribute and help others. It can rule your life also.
    Hope this helps. But be careful! take control of your brain health!
  • I want thank everyone for their comments. I especially want to thank Metalneck for recommending Rhodes Pharma version of morphine sulfate sold at Walgreens, which I intend to try.

    I checked the "inactive ingredients" of MS Contin and four generic versions. The generic versions of morphine sulfate manufactured by Watson Labs and Rhodes Pharmaceutical are shown on their respective package inserts to have exactly the same "inactive ingredients" as MS Contin, the brand name drug manufactured by Purdue Pharma. The generic versions of morphine sulfate manufactured by Mallinckrodt and Endo have some different "inactive ingredients".

    More specifically, the Mallinckrodt product includes Hydroxypropyl methylcellulose in place of Hydroxyethyl cellulose, Lactose monohydrate in place of lactose, silicone dioxide in place of talc, and triacetine added for unknown reasons. FD&C Blue No. 2 is substituted for FD&C Blue No. 1. As I said, I am no pharmacologist, and I don't know which of these changes made me sick, but I can say unequivocally that this product made me sick.

    I have searched the web and found several similar complaints from morphine users, and I believe that Mallinckrodt is selling an inferior product.
  • Hi there...

    The actual federal law is written so that all generics have the exact same ACTIVE ingredients...but yes...they can all have different inactive ingredients up to 20% difference..

    I have to disagree with pcyoung that says that long acting medicine has a stronger effect than short acting...the half life is of importance in any medication...for something like Percocet...it's only 4-6 hours...so a 10mg will release all the medicine at once...then within 45 minutes or so be at the peak...then taper down the next hours..

    A 10mg of Oxycontin...exact same ingredient of oxycodone...will release 5mg within the first 45 minutes...at it's peak...then taper down within the next 5 hours and 15 minutes...at the 6 hour mark...it releases the next 5mg....and same release until 12 hours total from start to finish...

    That is why most PM's will not prescribe a short acting medicine as a primary...the brain will actually build tolerance to this much quicker than a long acting medicine...as well as how much less effective it is for a smooth and constant pain control like a long acting medicine provides.

    That is why it makes no sense to a chronic pain patient to take short acting medicines...they are only meant for 'breakthrough' pain as needed...The long acting medicines last 8, 12, or 24 hours depending on the medicine.

    This is why people with SA meds have such up and downs with their pain...they have to keep taking medicine every 4 hours to acheive the relief...

    I am good friends with my PM who is an Anethesiologist who specializes in pain medicine. We discuss these and other very interesting things over lunch or coffee...as well as being on medicine and learning things for over 10 years..

    If anyone is becoming a zombie on their medicine...it's likely you are taking too much...the dosage is too high...

    Just wanted to clarify and we can agree to disagree psyoung..

    *To the OP...I am prescribed the generic MSContin both 30mg to take every 12 hours and the 15mg so I can choose to add either one to a dose instead of stuck with just 30mg...so my total for the day (24 hours) is 60, 75 or 90mg a day depending on the pain levels or activity I know I will have.

    I have no insurance so pay out of pocket. I get mine...ENDO pharmaceutical...at Sam's club...it's less expensive there than at Walmart actually even though it's the same company...they get a better rate...And you do NOT have to be a member to use the pharmacy at box stores...it's illegal....

    I have had wonderful coverage and limited side effects...which was some nausea and fatigue when I first started but dissapated within a few weeks..

    I use OxyIR 5mg for breakthrough pain as needed...As well as a muscle relaxer too when needed.

    I think it's really an individual thing...keep in mind that online...with anything...you will most often only get complaints...people don't post on websites when they are happy...so just take those complaints with a grain of salt...

    I used Mallinckrodt products before and had no issues...I think it's really specific to each person with the inactive ingredients and issues...

    I've never heard or seen Rhodes listed as a generic on any of my meds...but if it works for you...great..

    If you need to switch again...call around to Sam's or Walmart to ask for Endo brand and see if that works..

    I wish you luck:)

  • I am a very ill person , I am on dialysis 13 hours a night .To make a long story short, I am suffering from ischemic colitis , recently discovered dead tissue in my bowels. I am on peritineal dialysis , which is quite painful , I am on 150 mcg fentanyl every 48 hours.
    When I picked up my prescription from the pharmacy it was for this horrible brand!
    It makes me violently ill with a constant headache, forget about helpiing the pain.
    I do not know what to do.
    I dont know if my dr will write another script , but if she does , how will I fill it?I am sure my insurance wont pay for it, they just paid for that other sfuff,What horrible medicine.I can not do dialysis without pain medicine.
    Any suggestions?"
  • Hi, Nancrlong77

    Wow, that's scary! Most of us on Spine-Health are suffering from pain, but your condition is much worse than mine. I hope someone else with more experience with patches will also respond, but let me start.

    I tried a fentanyl patch once. It gave me a terrible headache, so I ripped off the patch and never tried fentanyl again. I don't know whether it was a generic, I don't know what the manufacturer was, and I think we threw away the box after keeping it around for more than a year. So I cannot be of any help with fentanyl.

    I might have something to add about how to deal with insurance companies. When I had the problem with Malinckrodt morphine sulfate ER, I called the insurance company as well as the manufacturer. The insurance company representative told me that there are differences between generic pills, including the "inactive ingredients", the fillers and the coating. The insurance company said if I got a new script, they would honor it. I could choose whether to try another generic or I could try a brand name product. If I wanted a brand name product, I needed to ask my doctor to write on the script "Brand name medically necessary". I asked my doctor to do this once so that I could try the brand name MS Contin and make sure that my nausea was not caused by the morphine itself. Sure enough, the brand name medicine did not cause nausea for me.

    I have been getting my prescriptions from my internist, but I am pretty sure that my pain management doctor would be as accommodating if I had gone to him.

    The brand name medicine is expensive. So on my last visit to my internist, we discussed it, and we decided I should try the generic morphine tablets manufactured by Rhodes Pharmaceutical, as recommended by Metalneck. I am glad I did. I can distinguish no difference between the Rhodes product (sold by Walgreens) and the MS Contin manufactured by Purdue. They have the same "inactive ingredients" and I feel the same. That is, I wish I did not need to take morphine, but it helps my pain with tolerable side effects.

    I would recommend that you send a PM (private message) to Ron Dilauro, who is an administrator on this site. He knows more about patches than I.
  • Too much opiods ( fentanyl especially) will make you feel sick . If your metabolic functions are compromised i would ask your dr to try lower dose only when you hurt and a 50 mcg for chronic pain - but thatz only my opinion
    but i have experienced headache and nausea - sick feeling
    from fentanyl - sleep disturbences etc
  • pill formulation has effect on drug efficacy - Anacin vs regular aspirin with caffiene - Anacin works better - why? I believe it has to do with how rapidly the compounded pill becomes hydrated, if any of the inactive ingedients form a colloid or bind more favorably with the drug , the size, distribution of the drug particles, any effect fillers have on stomach lining etc although considered inactive these are not inert!
    variations in microchemistry can alter soluability of drugs and how fast they solvate across the stomach lining into the bloodstream
    so method to make drug is not the same as drug formulation.
    Some contin like meds has dramatically different mechanisms to delay solution and access to stomach, intestine lining such as colliods , waxes and co soluable micelles which allow diffusion of drug - but people and their stomachs, diets are different - statistical testing shows only average values- just like side effects -
    people are more different than similar in the details - we have ranges that change ( like blood pressure)
    Conclude: diff pill manufacturers have diff effects diff people
  • MetalneckMetalneck The Island of Misfit toysPosts: 1,675
    Im so glad that the Rhodes brand seemed to work well for you.

    Its nice to know that we (although gardedly) can maybe sometimes point someone in a direction that may assist in this journey called pain management and life.

    Thank you for the honorable mention. It is apreciated.

    Nancrlong - As to Mallinckrodt making Fentnyl patches ... I wasn't even aware that they did. But I can tell you from my experience that I have had problems with both the Watson and Mylan brands and Only the Sandoz
    seemed to work for me. Sandoz is supposedly manufactued at the same plant as the name brand Duragesic by J&J. But last I heard the Sandoz brand was on "Factory Backorder" with no known date for new shipments available.

    As far as your insurance goes .... If you can get your doctor to write a new script - different strength or timing (Sig) I believe the insurance company will have to honor it as it is viewed as a new perscription ... not an early or duplicate of the previous. You can always attempt to speak to the quality assurance - untilization review department at your insurance company and attempt to explain the situation to them and obtain a pre-approval for the new/altered RX.

    Praying for continued strength and assitance for us all,

    Spine-Health Moderator
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  • All i can say is that tolerance to meds are their own set of issues- more medication causing ones body to try and compensate - so keeping as low a dose of meds is important for longer term prognosis of overall health - mental issues such as depression which can result from taking too much med over too long of time
    for me chronic pain has me worried enough and i desire as long a life as possible
    when i first started taking strong meds for pain i was scared by seeing many deteriorate after many years of taking increasing doses -
    perhaps philisophically i believe we have to pay for any imbalances. With short acting you can at least give your nerves and receptors a chance to recover.
    Its been almost 16 years since i started taking meds for chronic pain and i pray my body and mind do not decline. Especially mental and the battlefield of chronic pain is in the mind.
  • Lovtotravel: I am not sure that I wrote that short acting opiods are stronger than extended release.
    The point I was trying to make is that with continued use tolerance builds up. Taking longer acting medications serves to expose your body and nervous system to constant concentrations of these medications.
    Neuroplasticity is a phenomenon which is responsible for our body and mind to adapt to constant conditions. This is one of the factors responsible for developing tolerance.
    Both tolerance to the dose and that dose's ability to reduce the pain compared to its effectiveness months before (if one were taking the same dose day after day for months).
    Your nervous system. Your synapses and your endrocrine system all compensate for these constant levels of drugs.
    My point was that with short acting opiods one has the choice to reduce the concentration in your body on those days when the pain is not as severe.
    Chronic pain does not mean you have exactly the same levels of pain each and every day.
    In being able to reduce the concentration in ones system you give your brain and your body some time to readapt to lower concentrations reducing tolerance effects and reducing the effect on ones brain activity and nervous system to the same dose day after day.

    The reason I bring this up is that I have known a number of chronic pain patients who take the long acting opiods as prescribed and it seems they deteriorate mentally faster and the relief they obtain seems to be less.
    My experience is that taking long acting medications your mind never has the opportunity to clear itself. I am very fond of my mental acuity and do not wish to lose it.

    The effect of these long acting medications over long periods of time is depressing overall to your system.

    Perhaps I am wrong but I have been able to maintain my faculties by making certain that when I can I reduce the medications sometimes even if it means more pain- why? because one's intellect is one's life and spirit and soul if you like.
    Pain is crippling enough without numbing your brain as well. I have just seen too many chronic pain patients who are miserable after years and I belief that if they could somehow reduce the levels once in a while to recuperate they may regain their intellect and their sense of participation in the real world.
    I hope this makes more sense to you.

    This would mean that if you take
  • Some people say that when one becomes tolerant to one opiod, one can change to a different opiod. Is that true? For example, if one become tolerant to hydrocodone, can one switch to oxycodone or codeine? And then switch back to hydrocodone in a year?
  • But check with your doctor for this kind of advice. I am not a medical professional and do not rely on my opinion in lieu of medical advice.

    I can offer you my opinion below

    No. Opiods all act on the same receptors. There are different chemical forms each exhibiting a different degree of effectiveness for pain relief. Some, like methadone, have little if any euphoric side effects and dubious pain relief efficacy.
    The difference between these will be the quantity you must take to achieve the same pain relief. Although pain relief is complicated by side effects. Some opioids have less respiratory depression, such as fentanyl, this can lead to hypoxia which produces headache.

    Those individuals who are bed ridden and who respiration is already compromised may experience such severe respiratory depression as to cause nightmares and nausea and headaches.

    Opioids are a blessing and can be a nightmare if one is not careful with their use. Never substitute one for the another opioid with the belief that it produces less tolerance, dependence or addiction.

    The mechanism of action is paramount to their effectiveness and any differences represent a change and disorientation by the patient. It can lead to anxiety and doubt as to their effectiveness.

    Psychologically; we get used to a specific medication and when the side effects change or any other aspect of the medication changes - it can lead to problems.
    My father's doctor (my father was taking opioids for his lung cancer pain) suddenly changed medications from oxycotin to diluadid. Even though the diluadid was more effective my father went through a very difficult transition period due to the change in medication.
    Be careful and make certain you obtain medical advice from a pain specialist before changing anything yourself.

    My opinions are simply that and may not apply to anyone else. Pain management and taking narcotics is serious business and when over prescribed can affect our better judgment.

    I hope that helped. I can provide you a website if you like. But check with your doctor for this kind of advice.

  • My experience with the Rhodes generic morphine sulfate extended release tablets has been positive. This product seems to work the same as MS Contin. However, recently I have been having trouble finding it. Three Walgreens did not have it in stock. We ordered it, which takes eight days. I was wondering whether anyone else has been trouble with the availability of this product.
  • BTW, I found out that Rhodes Pharmaceutical is a small company with 13 employees.
  • Morphine sulfate ER is specifically designed to be used consistently at scheduled times to treat chronic pain. This prescription medication is a strong narcotic painkiller used when potent opioid medication is needed for a long period of time. Other than pain relief, morphine sulfate ER causes several different effects in the body, such as cough suppression, decreased breathing, and drowsiness. There are no off-label morphine sulfate ER uses at this time.


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    Post Edited by Authority Member Liz
  • with generics I have found there to be a differnce in brands, it seems the guidelines I am told is that in a generic it can be a plus 20 or neg 20 % comparison to name brand I have had a bad experience with mallinckrodt I talked to my pharmacist about this and he had rhode also in stock which made a significant differnce in my pain controll, I thought it was me, but had noticed the pharmacy I use had changed manufacturers I looked at the old bottle and the new and saw the different manufacturer, so I brought them in and asked the pharmacist if it was me or is there a difference he said there absoloutely can be a difference so I talked to him and he makes sure I get rhodes now, and recently asked if I would try the endo brand to see how they worked, I guess I shall see, I feel lucky that my pharmacist was so open and willing to explain and talk to me with out hype and judging as there seems to be a awful lot of that with people on pain meds
  • nancrlong77 said:
    I am a very ill person , I am on dialysis 13 hours a night .To make a long story short, I am suffering from ischemic colitis , recently discovered dead tissue in my bowels. I am on peritineal dialysis , which is quite painful , I am on 150 mcg fentanyl every 48 hours.

    When I picked up my prescription from the pharmacy it was for this horrible brand!
    It makes me violently ill with a constant headache, forget about helpiing the pain.
    I do not know what to do.

    I dont know if my dr will write another script , but if she does , how will I fill it?I am sure my insurance wont pay for it, they just paid for that other sfuff,What horrible medicine.I can not do dialysis without pain medicine.
    Any suggestions?"
    I am so sorry to hear about your bad luck at the pharmacy with getting a brand you do not like or find effective. My recommendation is to make friends with your pharmacist. They can always tell you what is in stock, and if you need something specific, ask them to order it for you a week in advance and show them your prescription. I just stopped taking fentanyl, and last year my insurance would make me pay $10 copay for the Brand and $50 for any generic. You must call both your doctor and your insurance and tell them that the brand of generic fentanyl you just filled does not relieve your pain, you would like to return it and substitute it for "your choice generic that you like". Threaten with visits to the ER if your pain cannot adequately be relieved or whatever your dialysis will do for you to make it more expensive. ER visits are much more expensive than any other medication. I'm sorry to hear of your medical ailments and that you are on dialysis. Please hang in there. Call the doctor, the insurance company, and call the pharmacy where you filled it to ask the to order the medication you want.
    Chronic pain since 2007. Have scoliosis. Had ACDF surgery for C5 Dec 2011. Sick of dealing with pain. I just turned 32 and struggle through but work full-time in IT.
  • Hey Everyone, first post here. I am about to start the Morphine Sulfer 30's, twice a day, in addition to my breakthrough medication, oxycodone, also twice a day, but have extra for bad days. I have stopped the treatm:ents I was getting because the Dr was just ripping me off. But I've run the gammet on pain meds, from the Vicoden family through the loritab family Methadone, that caused liver problems, Oxycodone w/no aspirin, which is the one I'm on now along w/the Morphine. My concern is what kind of punch can I expect?
  • I agree that brand name drugs are better. i understand that it's the same exact active ingredients, but it's the inactive ingredients that make the difference in this instance. Sometimes it doesn't matter what the inactive ingredients are, or whether it's generic or not. People can react very differently to the same medications, so that's something to consider also. I'd stick to what works for you, even if it's the more expensive brand name. Someone gave good information when they told you that the doctor can get you approved for the brand name drugs by specifying that it's medically necessary. When a medication makes you sick when it's generics-then that's medically necessary!
  • First time poster here...

    I must agree that Mallinkrodt Morphine ER is VERY inferior to any other brand I've tried. Not only that, but I have noticed a significant fluctuation in effectiveness from batch to batch. The difference between brand name & generic drugs is most pronounced in any extended/controlled/time release pill. Even after a medication goes generic, the original manufacturer still maintains a patent on the time-release formulation. That has a large impact on bioavailibility, peak plasma levels, duration of action, time of onset, etc.

    My p-doc recommended Mylan over Mallinkrodt, but it is nearly impossible to find any pharmacy in Central Florida that carries anything other than those and the brand. Currently, I'm awaiting a new hearing for my disability case, so I'm on Medicaid. The HMO I have, United Healthcare, actually DOES make it possible to get the brand. All the dr. has to do is call a specific number, have a form faxed to him/her, and state the reason (either generic is less effective or patient has a bad reaction to ingredients in the generic), and then they will cover it 100%. I was really surprised, since lately most insurances won't cover a brand name without burying the dr. in paperwork.

    As someone who suffers from degenerative disc disease, extensive arthritis in every join & vertebral space in the spine, as well as having had a laminectomy which resulted in permanent nerve damage to my left leg, I am obviously on multiple medications. The way I see it, If there's any way to get the brand name, do it. We have enough to deal with, and as you all know, even a slight fluctuation in the effectiveness of our meds can make a world of difference, not to mention the risk of inactive ingredients made in 3rd world countries causing adverse reaction. That is my 2 cents (or more like 2 million dollars...lol)
  • FoxyredFFoxyred Posts: 1
    edited 09/23/2015 - 8:10 AM
    For, Old Whotebread, it looks like your post is old, but just an FYI in case you haven't already gotten an answer. I am taking ENDO generic MS Contin, and I get the same reaction you are getting. I'm nauseated, have stomach cramps and just feel basically crappy. I , too, know that it has something to do with the fillers,etc. They are using in this drug. I never got this with the Purdue brand, just pain relief. I think part of the problem is, whatever they are using as a binder to make it SR, or ER, isn't working well. I feel like it is dumping too much of the drug, as I find that my body seems to ,"need" the next does in 7 1/2 hours. It's prescribed every 8. With the Purdue brand , if I didn't need it, for pain, I could skip the in between dose and take it when I had pain, or 12 hours, as I would be in too much pain if I went longer. MY opinion, I think they are doing something that makes them more addictive, as I've been on MS Contin for 30+ years and never had any withdrawal symptoms from skipping a dose. I use to tage a,"drug holiday", from time to time just to be sure I didn't become tolerant as I don't want to have to increase my dose. On the ENDO brand, I am not able to do this. I've only taken this brand for 1 1/2 months. I am fortunate to have a physician that was a pharmacist for 20 years and then became a physician, I'm going to discuss this with her. I HATE this feeling and refuse to take meds that control me, instead of me controlling them! Late, but hope this helps.

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  • I had a very scary adverse reaction to a med I had been taking for several months, ( MS Contin 60 mg). I have been on pain management programs since 1998, due to severe chronic pain issues. I have tried nearly every drug out there. I was on Exalgo, but it became non-formulary, so mt MD changed me to 60mg MS Contin. I had no problems for about 5 months. This last visit, the pharmacy had changed manufacturer, and I thought nothing of it. The first night, I got cherry red cheeks, 2nd night I got purple cheeks, 3rd night my heart started to elevate and pound in my chest. I took an extra beta blocker (metoprolol, which I take for my B/P) and it resolved. 4th night my heart rate went up to 130's+ and my B/P was 164/97. I took an extra beta blocker and eventually called 911. I contacted my MD and he originally said that he thought it was the steroid shot in my neck I had received the same day it started. I disagreed. I take my usual beta in the morning and I felt that this covered me for the morning, but as it wore off snd ai took more pills in the evening, then it had free reign to wreck havoc. He changed me to Oxycontin 30 mg. It isn't as strong, but it doesn't set my heart on that hyper state. Has any one else had a similar situation w/this or other meds?
  • SavageSavage United StatesPosts: 6,273
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  • jra191jjra191 Posts: 11
    edited 11/01/2015 - 1:00 PM
    Well this thread is old and I was just going to say as far as ER morphine goes...I've been getting pills mfg'ed by a company called ZYDUS. All I wanted to say is I think this particular pill has lasted the longest for me as far as extended release. They are all about the same, but this one just seemed to last a little longer as far as pain relief goes. Now...I googled the website and read overall reviews on this company and almost everyone has been giving them one and two stars LMAO. Not just on pain medication, but everything. LoL I say tomato you say TOMATO ;p
    Rick Anderson. I live in middle Tennessee. I'm a former pro motocrosser, raced a car on dirt tracks for 5 years, played tennis in high school, now raising 2 kids and enjoying life to the best of my ability :)
  • I had been taking a generic MS Contin 60 mg for about 4 months, with no problems. The last time I had it filled, they didn't have my "usual", so they gave me the "new" ones. I didn't think any thing of it until I took the first one and that night my face was flushed and cherry red; the second night my face was hot and nearly purple. the 3rd night my heart started to race a little, so I took and extra dose of my beta blocker, blood pressure med. (I take one a day, which I take in the mornings). The 4th night, my heart started pounding out of my chest and was running about 120 and my blood pressure was 197/98. (With the beta blockers, my resting heart rate runs between 47 and 60 and my B/P around 117/60). I took and extra beta blocker and finally called 911 because it was taking so long for my heart to settle down. By the time the EMS got to the house, things were calming down, but still extremely elevated for my "norm". I didn't go to the hospital because things were getting better. I called my pain MD the next day and he changed my to Oxycontin 30 mg, which isn't as strong as the MS Contin, but I have had no further incidents of the heart problems. I believe that the reason I was only experiencing the reactions at night was because the beta blocker I take in the morning kept things in line and as the med wore off and I took the 2nd MS Contin at night, it allowed my the effects to my heart.
  • I had been taking a generic MS Contin 60 mg for about 4 months, with no problems. The last time I had it filled, they didn't have my "usual", so they gave me the "new" ones. I didn't think any thing of it until I took the first one and that night my face was flushed and cherry red; the second night my face was hot and nearly purple. the 3rd night my heart started to race a little, so I took and extra dose of my beta blocker, blood pressure med. (I take one a day
  • I had a 360 degree lumbar fusion, plus (2) newly invented artificial disc (no more rods & screws) surgery, 6 weeks ago. My primary care doctor did not write down that I am allergic to Dilaudid, and they gave it to me in the pump, post op. I started shaking really hard, I was freezing, and my blood pressure skyrocketed to 100/149., when they stood me up! Soon the room was filled with cardiologist, another doctor and the they were drawing my blood and asking me if I knew where I was and what year it was.

    Something told me to ask what was in my IV. When they said "Dilaudid", I announced my allergy, so they stopped it right then. They gave me 60MGS of Kadiian ER and 10MGS of oxycodone by mouth. 10 minutes later, I was fine.

    When I left the hospital, they gave me (2) prescriptions. One was for oxycodone and the other was for MS CONTIN. CVS called my house after we dropped them off to get filled, to say, I am allergic to MS CONTIN.

    I had to have my husband, drive all the way to the neurosurgeons office to pick up 60mgs prescription for Kadian ER, instead.
    The weird thing is, they both say, Morphine Sulfate ER. (in tiny lettering above, one says Kadian the other MS CONTIN)

    What specifically am I allergic to in MS CONTIN that is not in Kadian?
    I do not know the manufacturer of any of these medications, so some might think I am "off topic".
    Hoping it does not matter for what I am inquiring about.

    Who ever heard of their BP spiking to 100/149, because of Dilaudid?
    They told me, ONLY when they stood me up did my BP spike. It does not really seem like it is the med. The shaking and the freezing feeling, plus it really did nothing for my pain, was a another reason to stop it.

    Thank you for ANY feedback about Dilaudid, and differencee of MS CONTIN & KADIEN.
    So far, I have posted a few times, and I never get any feedback.

    "For we walk by faith, not by sight"~ Corinthians
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