Piriformis Syndrome and Sciatica While piriformis syndrome may cause symptoms similar to sciatica, it is a muscle condition only. Sciatica symptoms are caused by a spinal problem. Further Reading: Piriformis Syndrome Related Articles Stretches and Exercise for Sciatic Pain from Piriformis SyndromeWhat is Piriformis Syndrome? Related Videos Piriformis Syndrome VideoPiriformis syndrome is an irritation of the sciatic nerve caused by the contraction of the piriformis muscle.Sciatica Exercises for Piriformis Syndrome VideoAn informative visual demonstration of correct exercises and stretching techniques to help relieve sciatica pain caused by piriformis syndrome. Sciatica Animated VideoSciatica is leg pain caused by a problem in the low back. Watch an animated video that details the causes and symptoms of sciatica.