My doc normally gives me lortab 10/500, this time she gave me lortab 10/325. I wasn't sure what the difference was, so called the pharmacy when i noticed they do not seem to be working all that well. He said it is the amount of tylenol in them. Would that make that big of a difference? We have had non-stop rain and wind and awful storms the past few days so I know that always intensifies all the pain, but my elbow joints and knees and ankles are just not getting much relief at all. It does o.k. on the nerve pain, but that isn't as good either. I thought about calling my doc and ask her to take these and order me the ones I normally take but I'm not sure if it makes that much difference or if it is the weather. Any answers?