My Doctor has prescribed Pristiq for my pain. It is I am told the newest version of Exffor. My question is how long does it take for it to start helping with the pain. I'm not sure if I can handle taking it as it is causing my anxiety to spike... Gawd, I can't stand that feeling of being anxious. I am also taking Remeron for anxiety. It seems wierd or scary to be mixing to antidepressants together but that's what my Doctor wants. :?