I would welcome some knowledge from others. My pm doctor has me on Opana ER 30mg 2xdaily and Opana IR 5mg 3xdaily. It has worked fairly well for about three months I guess but I am considering a change for a couple reasons. First I have been hurting bad daily for about three weeks and it isn't helping like it was. I would normally just think well maybe it's time to go up in dose but the highest I could go on Opana would be to 40mg 2xdaily instead of 30mg. I would consider my dose overall to be on the high end , maybe I am wrong. And if it's not doing the trick at this dose I think a change would be good. I have a meeting in a week and wanted to go to that meeting prepared. He is probably going to give me some options. He first suggested methadone and I don't know if that is the route I want to go so I would love to hear from others. What works, what doesn't. I would appreciate you sharing your experiences.