The substance used in the prolotherapy injection is a natural irritant agent. Examples include:
Sugar (dextrose or glucose) alone or in combination with glycerin and phenol
Sodium morrhuate (a purified derivative of cod liver oil)
During prolotherapy treatments for chronic back pain or other disorders, the agent is typically used with a local anesthetic (lidocaine, procaine or marcaine).
Prolotherapy involves a series of injections, reportedly ranging from 3 to 30 (average 4 to 10), depending on the back condition and the individual being treated. The prolotherapy injection series may cover 3 to 6 months with injections at 2 to 3 week intervals.
Take acetaminophen or hydrocodone bitartrate plus acetaminophen for pain, but not aspirin or anti-inflammatory medications which would inhibit the healing response
Apply ice to the area 3-5 times a day for 20 minutes each as needed
Do moderate exercise such as walking but avoid strenuous exercise or work with heavy lifting
Follow-up the prolotherapy injections with a good physical therapy program