Welcome, Friend!

It looks like you're new here. If you want to get involved, click one of these buttons!

Protect anonymity
We strongly suggest that members do not include their email addresses. Once that is published , your email address is available to anyone on the internet , including hackers.

All discussions and comments that contain an external URL will be automatically moved to the spam queue. No external URL pointing to a medical web site is permitted. Forum rules also indicate that you need prior moderator approval. If you are going to post an external URL, contact one of the moderators to get their approval.
There are no medical professionals on this forum side of the site. Therefore, no one is capable or permitted to provide any type of medical advice.
This includes any analysis, interpretation, or advice based on any diagnostic test

The main site has all the formal medical articles and videos for you to research on.

Bone Morphogenetic Protien (BMP) vs Graphs

AnonymousUserAAnonymousUser Posts: 49,578
edited 06/11/2012 - 7:23 AM in Back Surgery and Neck Surgery
I am faced with a dilemma that someone may have an opnion or experience with and could give me some feed back on.

I was diagnosed last month by a NS with cervical spinal stenosis at several levels, the worst being at the C6-7 level. He advised me to have anterior cervical fusion surgery soon and listed my condition as critical. I do not have faith in this NS since I learned later that he has been disciplined twice in other states. I have tried to find another NS or Ortho/Spine Dr to get a second opinion. After locating some other Dr's and scheduling appointments, I have learned that they use Bone Morphogenetic Protien (BMP) for fusion. After more reasearch, I have learned that the Dr's that I have selected are being sued by whisleblowers for off-label use of BMP. It has been discovered to cause life threatening problems, post-op. Several articles have been written by the Wall Street Jounal ref this problem. The Dr's being sued have alledgedly received large payments from the company that produces or sells BMP. Irregardless of the correctness of this report, I do not want to take on any additional risk by using this product in surgery. Cervical fusion is risky enough with conventional procedures. The use of BMP is suppose to stimulate bone growth and lessen the recovery time.

Has anyone had any experience with BMP? If so, what have been your results.

What to do?


  • I Have done alot of reading on the BMP lately, i was researching for someone else. I did read some in the wall street journal, If I were you I would keep looking for a diff. N.S. that you have faith in.
    what state are you in? PM me if you would.. patsy
  • hiya delta.....i see patsy has ladybug has posted...........she actually did some research for me[thankyou dear patsy!]..i have sent u a pm ok.........there does seem to be alot of people talking about this bmp stuff.........if i can get a surgeon to take it out i will but i have to find the money first.... :))( :))(
  • advertisement
  • My surgeon used graffs-I am doing fantastic! HE also used "bone putty" (according to the OR report). Anyone know what that is? Is that BMP?
  • Hi Shay, I just got my op report yesterday. I had my own bone, BMP(Infuse), and something called Connexus which is allograph, human demeneralized bone. I have heard it referred to as bone putty in some of the articles I read. Perhaps it is similar to what you have. Creepy that it comes from cadaver, but it is superprocessed and sterilized etc. My surgeon just fluffed off my concern saying, well it is cadaver origin, but it is sooo processed, not really. I'll post the link, Sue

  • Yesterday, I was just researching the INFUSE product used in my L4-5 fusion and I read several articles about this controversy with using it for C-spine as it is not approved for use that way. Very scarey reactions they are seeing with swelling and airway problems requiring tracheostomy. I would think it best to find a surgeon who will used approved products for cervical surgery. Rather deal with a hip donner site than a trach anyday. Goodluck, Sue
  • advertisement
  • I'm just 5 weeks post-op so don't have any experience to relate right now. My surgeon used BMP and autogenous bone harvested from the partial laminectomy that was part of my procedure. He did not take any bone from my hip.

    I have been reading some scary stories about BMP, but I still trust my surgeon's decision about what he did, and that he did the best thing for me. He has been a spinal surgeon for 28 years an and I have no reason to doubt him, as my overall surgical and post-op experience has been much better than expected.

    Sure, I could still have future complications, but I have no reason to worry about such things right now. I'm maintaining my positive attitude.

    Delta, if you are extremely concerned about this, you have every right to tell your surgeon you prefer not to use BMP, or that if you will allow it, you don't want them to use it off-label. They should honor your request. If not, I would find another surgeon.

    My surgeon invented a facet bolt for use in 1 or 2 level fusions and told me he recommended them for me (they are new, approved by the FDA in 2006). However, he also told me that if I preferred that he use screws and rods, he could do that, too.

    He was willing to use whatever hardware I was most comfortable with. He even told me he recently had a patient who had agreed to the facet bolts, but changed their mind the morning of surgery. He had not problem with that and used screws and rods for that patient. I did allow him to use the facet bolts, but was very pleased that he gave me the option. I became very comfortable with my surgeon since he is obviously completely open to working within his patients' comfort levels.
  • Delta, I had the BMP with my fusion. The ortho used the bone from the laminectomy and the BMP together.
    I had L3-S1 done.

    At about 8 weeks or so I was getting more pain after coming off my meds and had a CT scanat 12 weeks. The ortho could see the fusion starting but he also said I had what is called 'osteolysis' which is where the bone ajoining the fusion and the BMP 'softens" a bit while the fusion is taking.

    It sounded scary but is actually a good sign as it means that the fusion is occuring and I just had to take a few steps back and do a bit less while my back was more fragile.

    I know there are some scary stories about BMP but then again there are scary stories about anything if you look for them.

    I would be inclined to ask your Dr what his succes rate is with BMP.

    Blessings Sara O:)

  • HI, I'm just curios, and i might be wrong but the BMP grows right? what stops it from growing when its work is done? I have been reading some on the BMP trying to understand it better. but Im just getting more confused. what if it keeps growing where it shouldn't be growing?
    sorry if this sounds like a st-p-d ? but i cant think of no other way to ask? patsy

  • Thanks Cali-I do not think that the bone putty that the report speaks of is processed cadaver bone-simply because "donor bone from a bone bank" is also listed as something they used. So it says-donor bone,bone from spine, bone from hip, and bone putty.
  • Thanks to all who have responded to my post on BMP.

    After researching BMP and the risks associated with it, I have decided not to allow it to be used in my surgery. As I stated in my original post, I do not want to add any additional risk to my surgery. One of the most disturbing things that I have learned in addition to the risks, is that some DR's or "Key Opinion Leaders" are receiving large consulting fees for promoting the use of BMP, which in my judgement is unethical. Just as in polictics, we do not trust anyone that receivies money from someone that they are supporting legislation for.

    Here is what I have learned about BMP. It is alledged that Infuse Bone Graft has been illegally marketed for uses that were not approved by regulators. It is now linked to life-threatening complications when used in an unauthorized way. Complications include difficulty in swalloing and breathing and can require tracheotomies and additional surgeries to repair. So far the FDA has received reports of 38 adverse events over a four year period. It is illegaly to use BMP in an off-label manner, meaning, used in a way that was not approved by the FDA. Anterior Cervical Fusion is an off-label procedure, along with others. In some institutions, BMP is no longer authorized for use because of the risks.

    The important issue here is that patients should make an educated and informed decision as to the procedure to be used in their surgery. Ask your Dr if they are paid consultants or have any financial connection to the company that maufactors the devise or product they are using and do your own research regarding the devise or product.

    As I said earlier, I do not want to take any andditional risk with my surgery. The surgery itself is risky enough with conventional methods. I also do not want to use a Dr who has finacial connections to the companies that manufactor the product or devise they use, that to me seems like a conflict of iterest.

    If you are interested in learning more about BMP, google "google news", Infuse Bone Graft, or Bone
    Morphogenetic Protein (BMP).

    Make an informed decision!
Sign In or Register to comment.